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Farrin Manian

Farrin A. Manian


MD MPH FACP FIDSA FSHEA, Massachusetts General Hospital/Harvard Medical School



Boston, MA, USA


Board-certified internist, completed a research fellowship in decision analysis. Currently working as an attending physician at Massachusetts General Hospital/Harvard Medical School in Boston, MA and as a Senior Consultant at Wing Tech Inc.


1976 Bachelor of Arts Biology, Magna Cum Laude University of Missouri-Columbia7/81-6/84 Resident


  1. Powers JS, Berger C, Manian FA, Kuhn K, Lichtenstein MJ, Billings FT. A Teaching Nursing Home: The Vanderbilt Experience. South Med Journal. 1986; 79:267-271.

  2. Manian FA, Alford RH. Ticarcillin plus clavulanic acid activity against ticarcillin-resistant Pseudomonas aeruginosa: discrepancies between disk diffusion and broth susceptibility studies. Antimicrobial Agents and Chemotherapy. 1986; 30:35-38.

  3. Maloney JM, Gregg CR, Stephens DS, Manian FA, Rimland R. Infections caused by Mycobacterium szulgai in humans. Rev Infect Dis. 1987: 9:1120-1126.

  4. Stratton CW, Franke JJ, Weeks LS, Manian FA. Comparison of the bactericidal activity of ciprofloxacin alone and in combination with selected antipseudomonal beta-lactam agents against clinical isolates of Pseudomonas aeruginosa. Diag Microbiol Infect Dis. 1989; 11:41-52.

  5. Manian F, Rinke D. HIV Antibody Testing in Hospitalized Patients. South Med J. 1990; 83: 23-29.

  6. Manian FA, Meyer L. Comprehensive surveillance of surgical wound infections in outpatient and inpatient surgery. Infect Control Hosp Epidemiol. 1990;11:515-520.

  7. Manian, FA. Hepatitis B vaccination among physicians: a decade later. Infect Control Hosp Epidemiol. 1991; 12:576.

  8. Manian FA, Meyer L. Comparison of patient telephone survey with traditional surveillance and monthly physician questionnaires in monitoring surgical wound infections. Infect Control Hospital Epidemiol. 1993; 4:216-218.

  9. Manian FA, Meyer L, Jenne J. Puncture injuries due to needles removed from intravenous line: should the source patient be routinely tested for blood borne infections? Infect Control Hospital Epidemiol. 1993; 14:325-330.

  10. Manian FA. Simultaneous measurement of antibodies to Epstein-Barr virus, human herpesvirus 6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue syndrome: is there evidence of activation of a nonspecific polyclonal immune response? Clin Infect Dis 1994; 19:448-53.

  11. Manian FA. A prospective study of daily measurement of C-reactive protein in serum of adults with neutropenia. Clin Infect Dis 1995;21:114-21.

  12. Manian FA, McKenzie DS. A prospective study of 2,092 “curbside” questions asked of two infectious disease consultants in private practice in the Midwest. Clin Infect Dis1996;22:303-7.

  13. Manian FA, Meyer L, Jenne J, Owen A, Taff T. Loss of antimicrobial susceptibility in aerobic Gram-negative bacilli repeatedly isolated from patients in intensive-care unit. Infect Control Hospital Epidemiol 1996; 17:222-6.

  14. Pirwitz S, Manian F. Prevalence of use of infection control rituals and outdates practices: education committee survey results. Am J Infect Control 1997; 25:28-33.

  15. Manian FA, Meyer L. Adjunctive use of monthly physician questionnaires for surveillance of surgical site infections after hospital discharge and in ambulatory surgery patients: report of a seven-year experience. Am J Infect Control 1997; 25: 390-394.

  16. Manian FA, Meyer L. Surgical site infection rates in patients who undergo elective surgery on the same day as their hospital admission. Infect Control Hosp Epidemiol, 1998; 19:17-22.

  17. Manian FA, Griesenauer S. Lack of agreement between tympanic and oral temperature measurements in adult hospitalized patients. Am J Infect Control 1998;26:428-30.

  18. Buller RS, Arens M, Hmiel SP, Paddock CD, Summer JW, Rickihisa Y, Unver A, Gadrealt-Keener M, Manian FA, Liddell AM, Schmulewitz N, Storch GA. Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. New Engl J Med 1999; 341:148-55.

  19. Manian, FA. New-onset rhinitis symptoms among hospitalized patients: are flowers a culprit? Infect Control Hosp Epidemiol 2001; 22:111-113.

  20. Manian, FA, Senkel D, Zack J, Meyer L. Routine screening of newly-admitted patients for MRSA in a community rehabilitation unit. Infect Control Hosp Epidemiol. 2002;23:516-9.

  21. Manian FA, Meyer PL, Setzer J, Senkel D. Surgical site infections associated with methicillin-resistant Staphylococcus aureus: do postoperative factors play a role? Clin Infect Dis. 2003;36:863-68.

  22. Walling HW, Manian FA. Predictive value of leukocytosis and neutrophilia for bloodstream infection. Infect Dis Clin Pract 2004;12:2-6.

  23. Manian FA, Ponzillo J. Compliance with routine use of gowns by healthcare workers and non-healthcare worker visitors on entry into the rooms of patients under contact precautions. Infect Control Hosp Epidemiol 2007;28:337-34.

  24. Manian FA, Aradhyula S, Greisnauer S, Senkel D, Setzer J, Wiechens M, Meyer PL. Is it Clostridium difficile or something else? A study of 352 hospitalized patients with new-onset diarrhea. South Med J 2007;100:782-86.

  25. Manian FA. Griesnauer S, Senkel D, Setzer JM, Doll SA, Perry AM, Wiechens M. Isolation of Acinetobacter baumannii complex and MRSA from hospital rooms following terminal cleaning and disinfection: can we do better? Infect Control Hosp Epidemiol 2011; 32:667-672.

  26. Manian FA, Gillman M, Spitznagel E. Clarity or confusion? A comparison between rankings of top hospitals by the U.S. News &World Report and the Consumers Reports overall patient ratings in major metropolitan areas in the United States. J Consum Health Internet 2012;16:162-69.

  27. Manian FA. Fever, abnormal white blood cell count, neutrophilia, and elevated serum c-reactive protein in adult hospitalized patients with bacteremia. South Med J 2012: 105(9):474-478.

  28. Manian FA, Griesnauer S, Bryant A. Implementation of hospital-wide enhanced terminal cleaning of targeted patient rooms and its impact on endemic Clostridium difficile infection rates. Am J Infect Control 2013; 41:537-41.

  29. Manian FA, Griesnauer S, Senkel D. Impact of terminal cleaning and disinfection on isolation of Acinetobacter complex from inanimate surfaces of hospital rooms. Am J Infect Control 2013;41:384-5.

  30. Turabelidze, G, Gee JE, Hoffmaster AR, Manian FA, Butler C, Byrd D, Schdknecht S, Chavez L, Duncan M, Ferrrett R, Evans D, Talley C. Contaminated ventilator airflow sensor linked to Bacillus cereus colonization of newborns. Emerg Infect Dis 2013; 5:781-83.

  31. Manian FA, Manian CJ. Sleep quality in adult hospitalized patients with infection: an observational study. Am J Med Sci 2015;349:56-60.

  32. Manian FA, Kelly E. Lower extremity acute bacterial skin and soft tissue infection following total knee arthroplasty. Am J Med Sci 2016; 352;154-8.

  33. Van Hise NW, Bryant AM, Hennessey EK, Crannage AJ, Khoury JA, Manian FA. Efficacy of oral vancomycin in preventing recurrent Clostridium difficile infection in patients treated with systemic antimicrobial agents. Clin Infect Dis. 2016; 63:651-3.

  34. Van Hise NW, Manian FA. Efficacy of oral vancomycin in preventing recurrent Clostridium difficile infection in patients treated with systemic antimicrobial agents (Reply letter). Clin Infect Dis 2016;63:1392-3.

  35. Blair A, Manian FA. Coexisting systemic infections in patients who present with a fall. Am J Med Sci 2016; 353:22-26.

  36. Manian FA, Hsu F. Writing to learn on the wards:scholarly blog posts by medical students and housestaff at a teaching hospital. Medical Education Online 2019; 24:1,1565044.


Other peer-reviewed publications


  • 1. Manian FA, Stone WJ, Alford RH. Adverse antibiotic effects associated with renal insufficiency. Rev Infect Dis 1990; 12: 236-249.

  • 2. Manian FA. Vascular and cardiac infections in end-stage renal disease. Am J Med Sci. 2003;325:243-50.

  • 3. Assi M, McKinsey DS, Driks, O’Connor MC, Bonacini M, Graham B, Manian FA. Gastrointestinal histoplasmosis in acquired immunodeficiency syndrome: report of 18 cases and literature review: Diag Microbio Infect Dis 2006;55:195-201.

  • 4. Manian FA, Alford RH. Infectious balanophosthitis in neutropenic hosts. South Med J. 1987; 79:909-910.

  • 5. Morrow J, Manian F. Candida glabrata vertebral osteomyelitis. Tenn Med J. 1986; 79:409-410.

  • 6. Morrow JD, Manian FA, Clinton ME, Stein RS. Eaton-Lambert syndrome in a patient with acute T cell lymphocytic leukemia. South Med J 1988; 81: 1578.

  • 7. Manian F, Bo-Linn G. Pseudoabscesses of the liver due to a contaminated isotonic medium. Res Medica. 1989; Vol.4,No.4:19-20.

  • 8. Manian F, Weidner J, Costello J, Fishbein D, Dawson J. Human Ehrlichiosis. Missouri Med. 1989; Vol.86,No.10:691-695.

  • 9. Garner K, Manian F, Fulk B. Q-Fever from an exposure to infected goats in Southern Illinois. Res Medica. 1991; 6:12-15.

  • 10. Manian FA, Kindred M, Fulling KH. Chronic varicella-zoster virus myelitis without cutaneous eruption in a patient with AIDS: report of a fatal case. Clin Infect Dis 1995;21:986-8.

  • 11. Manian FA. Cellulitis associated with an oral source of infection in breast cancer patients: report of two cases. Scand J Infect Dis 1997;29:421-427.

  • 12. Senkottaiyan N, Hafidh S, Manian FA, Alpert MA. Valvular and perivalvular involvement in patients with chronic kidney disease. J Geriat Cardiol 2005; 2:172-177.

  • 13. Aradhyula S, Manian FA, Hafidh S, Bhutto SS, Alpert MA. Significant absorption of oral vancomycin in a patient with Clostridium difficile coliis and normal renal function. South Med J. 2006; 99:518-520.

  • 14. Vedire S,Alpert MA, Ren J. Manian FA. Fusobacterium Necrophorum endocarditis in a previously healthy young adult. Am J Med Sci 2007;334:125-27.

  • 15. Reuter MD, Manian FA, Kershaw MA, Alpert MA. Herpes simplex virus type 2 encephalitis in an elderly immunocompetent male. South Med J 2007; 100:1143-46.

  • 16. Manian FA. The lesser of evils. Hektoen International; A Journal of Medical Humanities 2010; 2, issue 3 (online). Available:

  • 17. Manian FA. Who do I look like? Hektoen International: A Journal of Medical Humanities 2014;6, issue 3 (online). Available:

  • 18. Manian FA. The role of postoperative factors in surgical site infections: time to take notice. Clin Infect Dis 2014; 59:1272-6 (Editor’s Choice).

  • 19. Manian FA. Time to dedifferentiate. South Med J 2015;108:198-9.

  • 20. Manian FA. Unprepared for the end stages of end-stage kidney disease. Health Affairs 2015; 34:1599-1602.

  • 21. Manian FA. End-stage kidney disease (author’s reply). Health Affairs 2015;34:2005.

  • 22. Manian FA, Barshak MB, Lowry KP, Basnet KM, Stowell CP. CPC: Case 27-2016. N Engl J Med 2016;375:981-91.

  • 23. Chiappa V, Gonzaolez RG, Manian FA, Deshpande V. CPC: Case 23-2016---A 46-year-old man with somnolence after orthopedic surgery. N Engl J Med 2016;375:370-378.

  • 24. Manian FA, Chiappa V. CPC: Case 23-2016---A 46-year-old man with somnolence after orthopedic surgery (Reply letter). N Engl J Med 2016;375:1805-1806.

  • 25. Bond A, Manian FA. Spinal epidural abscess: a review with special emphasis on earlier diagnosis. BioMed Res Int 2016;2016:1614328, http://dx/10.1155/2016/1614328.

  • 26. Manian FA. Still invisible after all these years. South Med J 2017;110:685-686.


Other scientific or medical publications/materials in print or other media Reviews, chapters, case reports, monographs and editorials


  • 1. Manian FA. Doctors and Nursing Homes: What one resident found. New Physician. 1984;33:12-3, 36-7.

  • 2. Lichtenstein M, Manian F, Billings F. Learning and teaching in a nursing home: a personal account. Trans Am Clin Climatol Assoc. 1983;95:105-114.

  • 3. Alford RH, Manian FA. Current antimicrobial management of tuberculosis. Curr top infect Dis 1987;8:204-26.

  • 4. Manian F. AIDS: pathogenesis and treatment. ASM News (book review). 1989; Vol.55,No.10:564-565.

  • 5. Manian FA. AIDS and infections of homosexual men (book review). ASM News. 1990; 56: 110.

  • 6. Wilson GL, Manian F. Critical care medicine: activities, advances, and implications for infection control. Asepsis. 1990; 12:2-7.

  • 7. Manian FA. The latest strategies for diagnosing and treating Lyme disease. Mod Med. 1992; 60:72-81.

  • 8. Manian FA. Is eliminating flash sterilization practical? Infect Cont Hosp Epidemiol. 1993; 8:479-480.

  • 9. Manian FA, Janssen DA. Curbside consultations; a closer look at a common practice. JAMA 1996; 275:145-7.

  • 10. Manian FA. Surveillance of surgical infections in alternative settings: exploring the current options. Am J Infect Control 1997; 25:102-5.

  • 11. Manian FA. Should we accept mediocrity? N Engl J Med 1998; 338:1067-70.

  • 12. Manian FA. A dying man on death row: testing the Hippocratic Oath. Med Econ 1999; 76:58-70.

  • 13. Manian, FA. Whither continuity of care? N Engl J Med 1999; 340:1362-3.

  • 14. Manian FA, Schaffner W. Hepatitis B vaccine. In Poland GA, Schaffner W, Pugliese G: Immunizing healthcare workers- A practical approach. 2000, Slack Inc.,Thorofare, NJ.

  • 15. Manian, FA. Physicians vs physicians. Arch Intern Med 2001; 161:801-2.

  • 16. Manian, FA. Infectious Disease Handbook, 2001. Doody’s Review Service (on-line). Available:

  • 17. Manian FA. Hospital-acquired Infection, 2002. Doody’s Review Service (on-line). Available:

  • 18. Manian FA. Terrorism. Guarding against prejudice. Med Econ. 2002;79:51-2.

  • 19. Manian FA. Hospital infection: from miasma to MRSA, 2003. Doody’s Review Service (on-line). Available:

  • 20. Manian FA. Meeting JCAHO’s Infection Control Requirements, 2004. Doody’s Review Service (on-line). Available:

  • 21. Manian FA. The APIC/JCAHO Infection Control Workbook, 2006. Doody’s Review Service (on-line) Available

  • 22. Manian FA. Manual of clinical problems in infectious disease, 2nd edition (book review). Gantz NM, et al, editors. Clin Infect Dis. 2006; 42:1510-11.

  • 23. Manian FA. Review of Exposure: A guide to sources of infections. 2006. Doody’s Review Service (on-line). Available:

  • 24. Manian FA. Best practices in infection control: an international handbook. 2007. Doody’s Review Service (on-line). Available:

  • 25. Manian FA. Review of Infection Control Program Guide. 2007. Doody’s Review Service (online). Available:

  • 26. Manian FA. Review of Bennett and Brachman’s Hospital Infections. 2007. Doody’s Review Service (online). Available:

  • 27. Manian FA. Review of Meeting the Joint Commission’s Infection Prevention and Control Requirements; a priority focus area. Doody’s Review Service (online). 2009. Available:

  • 28. Manian FA. Outbreak: investigation, prevention, and control in healthcare settings (2nd ed) (book review). 2010. Doody’s Review Service (online). Available:

  • 29. Manian FA. Review of Ayliffe’s control of healthcare-associated infection. Doody’s Review Service (online). 2009. Available:

  • 30. Manian FA. Prosthetic joint infection due to Haemophilus parainfluenzae after dental surgery. South Med J. 1991; 84:807-808.

  • 31. Manian, FA. Potential role of famciclovir for prevention of herpetic whitlow in the healthcare setting. Clin Infect Dis 2000; 31:e18-e19.

  • 32. Manian FA, Meyer L, Jenne J. Clostridium difficile contamination of blood pressure cuffs: a call for a closer look at gloving practices in the era of universal precautions. Infect Control Hosp Epidemiol 1996; 17:180-2.

  • 33. Manian FA, Chor P, Weaver ME, Logan WR. Acute glomerulonephritis and encephalomyelitis following group G streptococcal bacteremia. Clin Infect Dis. 1992; 3:784-785.

  • 34. Manian FA, Brischetto MJ. Pulmonary infection due to Exophiala jeanselmei: successful treatment with ketoconazole. Clin Infect Dis. 1993; 16:445-6.

  • 35. Manian FA, Smith T. Ganciclovir treatment of cytomegalovirus pneumonia in an immunocompetent host. Clin Infect Dis. 1993; 17:137-8.

  • 36. Manian FA. Blood stream infection in a patient with AIDS with Oligella ureolytica, Candida krusei, and Bacteroides species. Clin Infect Dis. 1993; 17:290-1.

  • 37. Manian FA. Liver abscess due to Listeria monocytogenes. Clin Infect Dis. 1994; 18:841-842.

  • 38. Manian FA. Review of Bennett and Brachman’s Hospital Infections. 2014. Doody’s Review Service (on-line). Available: .

  • 39. Manian FA. Review of Hospital Epidemiology and Infection Control, 4th Ed. 2012. Available:

  • 40. Manian FA. Review of Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections. 2014. Available:

  • 41. Manian FA. Localized hypertrichosis after infectious rash (“HAIR”). JAAD Case Reports 2015;1:106-107.

  • 42. Manian FA, Alame D. Case Records of Massachusetts General Hospital; a 28 year old woman with headache, fever, and a rash. N Engl J Med 2015; 372:1454-62.

  • 43. Manian FA. When a doctor’s father rejected dialysis, he didn’t expect what happened. Washington Post, Sept 21, 2015.

  • 44. Manian FA. Infections in the Immunosuppressed patient. Book Review. 2016. Available :

  • 45. Manian FA. Concise handbook of infectious diseases. Book Review. 2017. Available:

  • 46. Sampat HN, Berger R, Manian FA. When should I transfuse my patient with anemia? The Hospitalist, December 2017.

  • 47. Roberts M, Krason, D, Manian FA. How should a hospitalist manage a patient presenting with syncope? The Hospitalist, Jan 4, 2018.

  • 48. Geisler B, Liao J, Manian FA. In my hospitalized patient on warfarin should I consider a switch to a NOAC? The Hospitalist (in press).

  • 49. Roberts MA, Hillmann W, Manian FA. How do you evaluate and treat a patient with C.difficile-associated disease? The Hospitalist, Nov, 7, 2018.

  • 50. Manian, FA. Bioemergency planning: A guide for healthcare facilities. Book Review. 2019. Available:, in press

  • 51. Gibson D, Restrepo D, Sasidharan S, Manian FA. When is it safe to resume anticoagulation in my patient with hemorrhagic stroke? The Hospitalist 2019; 23: 12,14.



  • 1. Manian FA (editor and co-author). APIC Handbook of Infection Control. Association for Professionals in Infection Control and Epidemiology, Inc. 1997, Washington DC.

  • 2. Manian FA (author). Mosby’s Curbside Clinician: Infectious Diseases. Mosby, 1998. St. Louis, Missouri.

  • 3. Jennings J, Manian FA (editor and co-author). APIC Handbook of Infection Control (2nd ed.). Association for Professionals in Infection Control and Epidemiology, Inc. 1999. Washington DC.


Letters to the Editor


  • 1. Manian FA. Universal Precautions "Clarified"? Infect Control Hosp Epidemiol. 1988; Vol.9, 8:343-344.

  • 2. Manian FA, Stone WJ, Alford RH. Cefazolin-induced encephalopathy in uremic patients. Rev Infect Dis. 1991; 13:773.

  • 3. Manian FA. Pneumococcal bacteremia and the normal chest radiograph. Lancet. 1991; 337:799.

  • 4. Manian FA. Prosthetic joint infection due to Haemophilus parainfluenzae after dental surgery. South Med J. 1991; 84:807-808.

  • 5. Manian FA. Hepatitis C after needle-stick injuries. Ann Intern Med. 1992; 116:345.

  • 6. Manian FA. Central nervous system toxoplasmosis in AIDS. N Engl J Med. 1993; 18:253.

  • 7. Manian FA. Improving hepatitis B vaccination rates among surgeons. Infect Control Hosp Epidemiol. 1994; 5:581.

  • 8. Manian FA, Janssen DA. Use of parenteral antibiotics in neutropenic patients. J Clin Onc 1994; 12:2517-18.

  • 9. Manian FA, Meyer L. Clostridium difficile rates. Infect Control Hosp Epidemiol 1995; 63-64.

  • 10. Manian FA. Viral antibodies in chronic fatigue syndrome. Clin Infec Dis 1995; 21:709.

  • 11. Manian FA.Modern medicine and chaos theory. JAMA 1998; 279:836.

  • 12. Manian FA. Should we accept mediocrity? (response letter) N Engl J Med 1998; 339:638.

  • 13. Manian FA. Intradermal vaccination against influenza. N Engl J Med 2005; 352:1044.

  • 14. Manian FA. Use of procalcitonin to guide duration of antimicrobial therapy in intensive care units: proceed with caution. Clin Infect Dis 2012;54: 578.

  • 15. Manian FA. Bryant A. Does Candida species overgrowth protect against Clostridium difficile infection? Clin Infect Dis 2013; 56:464-5.

  • 16. Manian FA. The role of postoperative factors in surgical site infections (response letter). Clin Infect Dis 2014; 60:1137-8.

  • 17. Manian FA. Seasonal variation of surgical site infections: Why does it occur, why does it matter? Infect Control Hosp Epidemiol 2016;371:121-3.

  • 18. Manian FA. Multidrug-resistant organisms in the rooms of patients in healthcare facilities. Infect Control Hosp Epidemiol 2017;38:630-31.

  • 19. Manian FA. Should we revisit the nephrotoxic potential of piperacillin-tazobactam as well? Clin Infect Dis 2017;65:178.

  • 20. Manian FA. A call for more involvement of infectious disease clinicians in medical education. Clin Infect Dis, 29 June, 2017. DOI:


Scholarly Clinical Blogs


Over 250 evidence-based blogs authored or edited at , “A Learning by Sharing Resource Dedicated to Hospital Medicine” (June 2015-Dec 2018)


Benjamin Franklin Prize (3rd place), Erasmus Scholarship, Ferring Award, Allianz StethosGlobe Scholarship, German Academic Exchange Service scholar, Official Runner-up for Parmley Prize


Loves traveling and Italian food

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